منابع مشابه
Urinary isothiocyanate levels, brassica, and human breast cancer.
Brassica vegetable consumption (e.g., Chinese cabbage) provides isothiocyanates (ITC) and other glucosinolate derivatives capable of inducing Phase II enzymes [e.g., glutathione S-transferases (GSTM1, GSTT1, and GSTP1) and NADPH quinine oxidoreductase] and apoptosis, altering steroid hormone metabolism, regulating estrogen receptor response, and stabilizing cellular proliferation. Asian populat...
متن کاملPolyamine levels in gynecologic malignancies.
Polyamines are closely related to many aspects of cell growth. Since increased amounts of polyamines in the urine of human cancer patients were reported in 1971, polyamines have been studied from the standpoint of tumor markers. In this study, polyamines in erythrocytes, plasma and urine were determined in 42 controls and 105 patients with gynecologic malignant tumors. The changes in polyamine ...
متن کاملAlterations in polyamine catabolic enzymes in human breast cancer tissue.
High concentrations of acetyl polyamines have been observed in human breast cancer compared with the equivalent normal tissue, however, no explanation as to the reason for the increases has been proposed. In this study, we show that changes in the enzymes responsible for the breakdown of acetyl polyamines occur in breast cancer tissue. Spermidine/spermine N1-acetyltransferase, the first and rat...
متن کاملChanges in polyamine acetylation in human cancer cells.
In the pancreatic-biliary diversion model, D F M O significantly reduced intestinal spermidine and spermine levcls and the spermidinc/spermine ratio. This was associated with a marked reduction or complete prevention of the adaptive mucosal hyperplasia in both the jejunum and the ileum 1201. D F M O has also been used t o inhibit intestinal growth in other experimental models. D F M O produced ...
متن کاملRegulation of polyamine acetylation and efflux in human cancer cells.
Introduction The polyamines spermidine, spermine and their diamine precursor putrescine, are normal and essential constituents of both prokaryotic and eukaryotic cells [l] . They are aliphatic polycations which are positively charged at physiological pH and are among the most cationic small molecules within the cell. Unlike the point charges of M$+ and Ca2+, the charge is distributed along the ...
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ژورنال
عنوان ژورنال: Cancer
سال: 1975
ISSN: 0008-543X,1097-0142
DOI: 10.1002/1097-0142(197502)35:2<464::aid-cncr2820350225>3.0.co;2-8